What type of study is this?

This is a Literature Review study.

September 10, 2025

The structural, functional, and diagnostic significance of NINJ1 in ferroptosis-related diseases.

Key Points

NINJ1 plays a critical role in the execution of cell death, particularly in ferroptosis, linked to cytokine storms.
Evidence shows that NINJ1 oligomerization leads to membrane rupture, creating significant implications for cell survival.
The role of NINJ1 in ferroptosis opens avenues for new diagnostic and therapeutic approaches for related diseases.
Understanding NINJ1 structure and function may enhance strategies to combat ferroptosis-associated pathologies.

Abstract

Ninjurin-1 (NINJ1) is the key executioner of inflammasome-induced plasma membrane rupture (PMR) in diverse forms of nonapoptotic regulated cell death (RCD), such as ferroptosis. Growing evidence suggests that NINJ1 protein oligomerization forms large, irregularly shaped pores in the plasma membrane, resembling a cookie-cutter mechanism. Hence, NINJ1 holds promise as a diagnostic and therapeutic strategy for ferroptosis-related diseases characterized by cytokine storms. Here, we review the function of NINJ1 based on its structure and summarize its potential applications in ferroptosis-related disease diagnosis.

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Cite This Study

Wang et al. (Fri,) studied this question.

synapsesocial.com/papers/68c193fb9b7b07f3a06185d9 https://doi.org/https://doi.org/10.1111/febs.70258

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