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September 10, 2025

Tumor microenvironment information transfer mechanism and diagnosis and treatment applications based on extracellular vesicles (EVs)

Key Points

Extracellular vesicles are crucial for facilitating communication in the tumor microenvironment, regulating cancer processes.
Key findings include the delivery of bioactive molecules that impact immune evasion and metastasis, influencing cancer outcomes.
The study examines the biogenesis mechanism and regulatory networks surrounding extracellular vesicles within tumors.
Understanding these processes may lead to novel strategies for improving cancer diagnosis and treatment approaches.

Abstract

Extracellular vesicles (EVs) serve as key mediators of cell-to-cell communication in the tumor microenvironment (TME), regulating tumor progression, immune evasion, and metastasis by delivering bioactive molecules such as nucleic acids, proteins, and metabolites. In this paper, we systematically analyze the biogenesis mechanism, microenvironment regulatory network, and clinical transformation prospect of EVs, and lay a theoretical foundation for the development of new cancer diagnosis and treatment strategies.

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Cite This Study

Yuze Zhang (Tue,) studied this question.

synapsesocial.com/papers/68c1a76954b1d3bfb60e0399 https://doi.org/https://doi.org/10.56028/aetr.14.1.1357.2025