Molecular design of NIR type I phenothiazine-based photosensitizers with aggregation-enhanced ROS generation for effective photodynamic therapy applications

Key Points

• Enhanced ROS generation was achieved through molecular design of phenothiazine-based photosensitizers.
• Four new photosensitizers were synthesized by integrating various electron donor groups to optimize performance.
• The study focuses on the design principles that improve photodynamic therapy applications using photosensitizers.
• Improved understanding of electron donor effects could lead to more effective treatments in photodynamic therapy.

Abstract