Genetic disorders are prevalent in Saudi Arabia due to high rates of consanguinity, making public awareness and attitudes toward genetic testing critical for national health strategies. This systematic review synthesized studies published between 2020 and 2025 from PubMed, Google Scholar, ScienceDirect, and the Saudi digital library, focusing on awareness, perception, and sociocultural influences on genetic testing in Saudi Arabia. The findings reveal generally positive public attitudes toward premarital screening (PMS) and genetic testing, with stronger acceptance among individuals with higher education or a family history of genetic disorders. However, barriers remain, including cultural resistance to altering marriage plans, limited knowledge, and low trust in genetic services. Sociocultural and religious beliefs strongly influence decision-making, with many couples proceeding with high-risk marriages despite unfavorable screening results. The review underscores the importance of integrating culturally sensitive education, expanding genetic counseling services, and leveraging public health initiatives to bridge the gap between awareness and behavior.
Alnefaie et al. (Tue,) studied this question.
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