Figure 2 from MYC is Sufficient to Generate Mid-Life High-Grade Serous Ovarian and Uterine Serous Carcinomas in a p53-R270H Mouse Model

Middle-age presentation of ovarian and peritoneal tumors. A, Lifespan data from mice euthanized due to tumor burden criteria. B, Example of a dissected reproductive tract from a mouse with obvious macroscopic ovarian tumors. C, Examples of widespread intra-abdominal disease, including liver invasion (L), peritoneal tumors (P), splenic tumor (S), and ovarian tumors (Ov). L, liver invasion; Ov, ovarian tumors; P, peritoneal tumors; S, splenic tumor.