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Endodontic therapy aims for thorough disinfection and three-dimensional filling of the root canal system, a goal often challenged by the complexity of root canal morphology. Traditional chemical irrigants and intracanal medicaments, such as sodium hypochlorite (NaOCl) and calcium hydroxide (CaOH2), are effective but can be cytotoxic and cause detrimental effects on periapical tissues and radicular dentin. Increasing antibiotic resistance and the adverse effects of synthetic agents have spurred interest in natural phytochemicals as alternatives. These phytochemicals exhibit promising antimicrobial, anti-inflammatory, and chelating properties, making them viable candidates for root canal irrigation, intracanal medicaments, and smear layer removal. The agents reviewed include Terminalia chebula Triphala, Camellia sinensis Green Tea , Curcuma longa Turmeric, Glycyrrhiza glabra Liquorice, Propolis, Melaleuca alternifolia Tea Tree Oil, Azadirachta indica Neem etc. These biomaterials have been studied in various combinations and against a variety of common intraoral bacteria like Enterococcus Faecalis. However, most of the conducted researches are in-vitro studies such as agar diffusion test. Despite their potential, there is a need for further comprehensive clinical and experimental studies to fully evaluate their biocompatibility, safety, and effectiveness compared to conventional treatments. This review aims to underscores the necessity of rigorous research and standardization protocols to confidently employ herbal extracts in endodontic practice. Keywords: Endodntic irrigants, Herbal irrigants, Intracanal medicaments, antibacterial, Glycyrrhiza glabra, Azadirachta indica, Aloe vera
THOMAS et al. (Sun,) studied this question.