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Abstract Nanogels offered a large surface area for biological conjugation due to their nanoscale size, enabling prolonged circulation in the bloodstream and targeted delivery to specific tissues. CMC/POM nanogels composed of 2-(2-(2-methoxyethoxy) ethoxy) ethyl methacrylate (MEO3MA), methacrylic acid (MAA) and natural biopolymer carboxymethyl cellulose (CMC), were synthesized via free radical polymerization. The chemical structures of CMC/POM nanogels were characterized using several techniques and the response behaviors under temperature and pH variations were reflected by changes in turbidity and particle size. The results demonstrated that CMC/POM nanogels exhibited significant changes in particle size and turbidity around 38°C and under different pH conditions. Additionally, the unique microstructure of CMC/POM nanogels made them promising for drug delivery through injection therapy. Choosing doxorubicin (DOX) as a model drug, the nanogels could achieve maximum drug loading content of 31.47% and drug loading efficiency of 62.93%. In vitro controlled drug releasing, the efficiency was up to 92.20% within 24 h at T = 45 ℃ & pH = 3.0. The cytotoxicity assays confirmed that CMC/POM nanogels possessed superior biocompatibility and drug-loaded CMC/POM nanogels effectively inhibited the activity of cancer cells. CMC/POM nanogels displayed remarkable potential as intelligent drug delivery systems and were expected to play an essential role in the field of anticancer therapies.
Cai et al. (Tue,) studied this question.