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Abstract Background Spinal cord injury (SCI) has a high mortality and disability rate and can result in severe neurological deficits and complications. The process of SCI is complex and has a long duration. Studies suggest that urocortin 2 (UCN2) is associated with motor functions regulated by the spinal cord. However, the role of electroacupuncture (EA) in regulating UCN2 at different times after SCI and its underlying molecular mechanisms remain unclear.Methods The SCI animal model was established in SD rats by complete transection of the right spinal cord at the T10 level. EA was applied to the T9 and T11 Jiaji points. Behavioral analyses were performed at 1-, 3-, 7-, 14- and 28-days post-injury (d.p.i), and cellular morphology was observed in spinal cord tissue obtained from the injury site. RNA sequencing was carried out, and the results were validated.Results The use of EA significantly improved the behavioral scores and hind-limb locomotion in rats with SCI at 7, 14, and 28 d.p.i (p Conclusion By modulating UCN2, EA can activate the downstream cAMP-PKA signaling pathway. This process improves the presence of astrocytes and microglia around the injury site, inhibits neuronal apoptosis, and increases the number of myelin sheaths and NF. As a result, hind-limb locomotor ability is restored in rats with SCI.
Hu et al. (Fri,) studied this question.
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