Repeatability and reproducibility of MRF-based Myelin Water Fraction maps of healthy human brains

Myelin Water Fraction (MWF) can measure White Matter (WM) myelination and integrity and can be quantified using Magnetic Resonance Fingerprinting (MRF) which allows short scan time. In this work, we assessed the repeatability and the reproducibility of MWF using 3D SSFP MRF in a traveling head study performed on healthy volunteers scanned at five different scanners from the same vendor. We computed coefficients-of-variation to estimate voxelwise variability in WM and GLM analysis to measure biases. We reported a variability of ∼3% for repeated scans at the same site and ∼5% for different sites, with an average bias of 5%.