Assessment of breast lesions using amide proton transfer-weighted imaging and dynamic contrast-enhanced MR imaging: a pilot study

MRI is a non-invasive method for breast lesions diagnosis. However, some imaging features of benign and malignant lesions in breast are still overlap. APT-weighted imaging (APTw) is a endogenous biomarker that allows non-invasive visualization of tissue composition and microscopic information for mobile proteins and peptides. The present study explores the feasibility of the combination of APT and dynamic contrast-enhanced MR imaging to assess of breast lesions. Results of this study indicate the APT value has significant difference between benign and malignant breast lesions.