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Accurate assessment of tissue viability is of great importance for the design of therapeutic interventions in acute stroke. 1H-MRSI and quantitative T2 imaging can provide neurochemical biomarkers sensitive to the pathological changes in stroke but their applications have been limited by long scan times. This study introduces a novel approach that combines fast high-resolution 3D-MRSI with quantitative T2 imaging to assess the viability of ischemic tissues in acute stroke. This approach achieved improved discrimination between ischemic brain tissues that ultimately infarcted and those recovered using joint neurometabolite concentrations and quantitative T2 values, in comparison with classical DWI and PWI methods.
Meng et al. (Wed,) studied this question.