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Dynamic glucose-enhanced (DGE) MRI is a dynamic chemical exchange saturation transfer (CEST) method that can provide information about D-glucose uptake in tissue. DGE signal changes are small and so-called pseudo-DGE effects can appear as true DGE effects. In this study, we investigated how motion and motion correction influenced the DGE effects using both a realistic (measured) motion pattern and an arbitrary motion pattern. We observed that pseudo-DGE effects are governed by the head motion pattern and originate either from tissue mixing at tissue interfaces or B0-shifts. Although motion correction can reduce these effects, new pseudo-DGE effects can also be introduced.
Lehmann et al. (Wed,) studied this question.