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Deuterium metabolic imaging (DMI) is a promising tool for studying tumor metabolism. In DMI 6,6’-2H2-glucose is uptaken by tumors, leading to the formation of HDO and of 3,3’-2H2-lactate as result of Warburg effect. DMI’s biggest challenge is SNR, consequence of 2H’s low Larmor frequency and the low concentrations of the targets. Depending on the type and size of the tumor, this can bring the key lactate signal below the noise level. This work explores weighted chemical shift imaging (CSI) methodologies for DMI based on SSFP sequences, providing improved lactate sensitivity over recently discussed CSI and multi-echo (ME) SSFP approaches.
Montrazi et al. (Wed,) studied this question.
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