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Background The therapeutic efficacy of an active Pharmaceutical ingredient depends on its solubility in body fluids. The low bioavailability of nearly 90% of new active Pharmaceutical ingredients and 40% of the existing molecules is attributed to their poor solubility. The current study aimed to improve the oral bioavailability of lapatinib by designing and optimizing nanostructured lipid carriers for it. Materials and Methods The formulation utilized the microemulsion technique as a method of preparation and the Box Behnken design was used for optimization. Results The average particle size, drug entrapment, and release, in percentages, were observed to be 237.09 nm, 72.32%, and 74.66% respectively. Conclusion In vitro studies proved that NSLC significantly releases a drug more than the marketed formulation.
Haritha et al. (Sat,) studied this question.
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