Interrelation of main laboratory indicators with the degree of liver fibrosis in patients with chronic viral hepatitis B

Objective . To establish correlations between laboratory parameters and the degree of liver fibrosis in patients with chronic HBV infection. Materials and methods . A retrospective analysis of clinical and laboratory data of 107 hospitalized patients with chronic hepatitis B (CHB) was carried out. During the study, indicators of a general blood count, biochemical blood test and coagulogram were studied, and predictive indices FIB-4 and APRI were calculated. The presence of correlations between laboratory parameters, predictive indices and the degree of liver fibrosis in patients with CHB was assessed. Results . In patients with F3 and F4, there was an increase in the level of ESR, total bilirubin, AST, ALP, GGTP and INR, and a decrease in the level of red blood cells, platelets and creatinine. The FIB-4 and APRI index values increased with the progression of fibrosis and had a direct correlation with each other. A direct correlation has been established between F (METAVIR) and the FIB-4, APRI indices, ALT, AST, GGTP, ALP, APTT, PT and INR levels. An inverse relationship was observed between the levels of red blood cells, hemoglobin, leukocytes, platelets and the stage of fibrosis. There was no correlation between the stage of fibrosis and the level of total bilirubin, creatinine, total protein and fibrinogen. Conclusion . Correlations have been established between individual laboratory parameters and the stage of liver fibrosis, which can serve as additional markers in the non-invasive diagnosis of liver fibrosis in patients with CHB.