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Abstract A palladium‐catalyzed 4+4 cycloaddition of aryl‐substituted γ‐methylidene‐δ‐valerolactones (GMDVs) with divinylketones (DVKs) was developed, providing an approach to access various mono‐cyclic tetrahydro‐2 H ‐oxocines with diverse substituents in 41% to 95% yield with 81:19 to >20:1 dr . This reaction was facilitated by anchoring olefin (C=C), carbonyl (C=O), and arene (Ar) at the α‐position of carbonyls.
Wu et al. (Fri,) studied this question.