Key points are not available for this paper at this time.
Abstract Background Klotho is a well-known anti-aging and antioxidant protein, however, the association between oxidative balance score (OBS), a comprehensive measure that assesses the individual’s oxidative balance, and serum Klotho concentrations is unclear. The purpose of this study was to explore the association between OBS and serum Klotho concentrations through a cross-sectional analysis of the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2016. Methods Serum Klotho concentrations were measured using an ELISA kit that is commercially available. OBS was scored by 16 dietary and 4 lifestyle factors. Weighted multiple linear regression models, subgroup analysis, and restricted cubic spline (RCS) analysis were used to assess the association between OBS and serum Klotho concentrations. Results A total of 8925 individuals who met the criteria were selected as eligible participants for the study. After adjusting for possible confounding factors, with the first quintile of OBS Q1(4–15) as a reference, the percentage change of serum Klotho concentrations in Q4(26–37) of OBS was 0.93% higher (95% CI:0.13%,1.73%). Serum Klotho concentrations rose by 0.40%(95% CI:0.09%,0.71%) with every standard deviation(SD) rose in OBS. In older, and over-weight participants, the subgroup analysis revealed a strong association between OBS and serum Klotho levels. Furthermore, the relationship between OBS and serum Klotho concentrations showed a linear positive association(nonlinear, p = 0.337). Conclusions A higher OBS is significantly associated with a higher level of serum Klotho among middle-aged and older people in the US.
Sun et al. (Fri,) studied this question.