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Aortic stenosis is known to cause mechanical obstruction of blood flow, leading to an increase in afterload pressure and, consequently, myocardial hypertrophy, resulting in diastolic dysfunction of the heart, ultimately causing diastolic heart failure (DHF). We evaluated transcatheter aortic valve replacement (TAVR) outcomes in patients with diastolic heart failure. This retrospective cohort study uses the National Inpatient Sample (NIS) 2020 database. We identified hospitalization with a diagnosis of DHF using the International Classification for the Tenth Division (ICD–10) codes. Within this population, we looked for hospitalized patients who had TAVR. Our outcomes of interest were in-hospital mortality, length of hospitalization, and the average cost of hospitalization (TOTCHG). The number of patients with TAVR and a history of diastolic heart failure (TAVRDHF) was 34435, while 41004 patients had TAVR with no history of diastolic heart failure (TAVRNDHF). The mean age of patients with TAVRDHF patients was 78. 2 years (SE=0. 12), while that of TAVRNDHF was 77. 3 years (SE= 0. 12). In-hospital mortality for TAVRDHF patients was 1%, while for TAVRNDHF patients was 1. 3%. There was a 24% decrease in the odds of mortality in TAVRDHF patients, while in TAVRNDHF patients, there was a 31% increase in the odds of mortality. The mean length of hospital stay for TAVRDHF patients was 3. 01 days (SE= 0. 78) and 3. 40 days ( (SE=0. 83) for TAVRNDHF. TOTCHG for TAVRDHF patients was 217, 871 (SE=6644) and 223461 (SE=5376) for TAVRNDHF patients, respectively. The proportion of TAVRDHF patients with a post-procedure complication was 0. 74%, while that of TAVRNDHF patients was 0. 64%. In this study, TAVRDHF was not an independent predictor of mortality, length of hospitalization, postprocedural complication, and total hospital cost.
Alugba et al. (Wed,) studied this question.