Mp22-04 Effects of Radiation Therapy to the Recurrence Sites on Oncological Outcomes in Patients Who Experienced Local Recurrence and/or Pelvic Lymph Node Metastases After Radical Cystectomy: A Multicenter Retrospective Study

You have accessJournal of UrologyBladder Cancer: Invasive II (MP22)1 May 2024MP22-04 EFFECTS OF RADIATION THERAPY TO THE RECURRENCE SITES ON ONCOLOGICAL OUTCOMES IN PATIENTS WHO EXPERIENCED LOCAL RECURRENCE AND/OR PELVIC LYMPH NODE METASTASES AFTER RADICAL CYSTECTOMY: A MULTICENTER RETROSPECTIVE STUDY Naoki Fujita, Toshikazu Tanaka, Shogo Hosogoe, Noritaka Ishii, Masaki Momota, Hiroyuki Ito, Ikuya Iwabuchi, Takahiro Yoneyama, Yasuhiro Hashimoto, Chikara Ohyama, Masahiko Aoki, and Shingo Hatakeyama Naoki FujitaNaoki Fujita , Toshikazu TanakaToshikazu Tanaka , Shogo HosogoeShogo Hosogoe , Noritaka IshiiNoritaka Ishii , Masaki MomotaMasaki Momota , Hiroyuki ItoHiroyuki Ito , Ikuya IwabuchiIkuya Iwabuchi , Takahiro YoneyamaTakahiro Yoneyama , Yasuhiro HashimotoYasuhiro Hashimoto , Chikara OhyamaChikara Ohyama , Masahiko AokiMasahiko Aoki , and Shingo HatakeyamaShingo Hatakeyama View All Author Informationhttps://doi.org/10.1097/01.JU.0001008608.50694.4b.04AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Local recurrence and/or pelvic lymph node metastases after radical cystectomy (RC) are often observed in patients with muscle-invasive bladder cancer (MIBC). Although chemotherapy and immune checkpoint inhibitors are main treatment strategies in such patients, radiation therapy (RT) to the recurrence sites might be one of the treatment options. However, its effects on oncological outcomes remain to be elucidated. METHODS: This multi-institutional retrospective study assessed 950 patients with MIBC who underwent RC. Of the 950 patients, 106 patients who experienced local recurrence and/or pelvic lymph node metastases without distant metastases were included. Patients were divided into two groups: patients who were treated with RT to the recurrence sites (RT group) and without (non-RT group). Multivariable Cox-proportional hazards regression analyses were performed to evaluate the effects of RT on cancer-specific survival (CSS) and overall survival (OS) after recurrence. RESULTS: The median age at recurrence was 72 years, and the median follow-up period after recurrence was 13 months. Of the 106 patients, 65 (61%) received neoadjuvant chemotherapy (NAC) and 30 (28%) were treated with RT after recurrence. CSS and OS were not significantly different between the two groups (Figures 1 and 2). In univariable analyses, NAC, pure urothelial carcinoma, tumor grade, and lymphovascular invasion were significantly associated with CSS. Similarly, NAC, pure urothelial carcinoma, tumor grade, lymphovascular invasion, and pathological lymph node involvement were significantly associated with OS. After adjustment for these confounding variables, RT to recurrence sites was not significantly associated with prolonged CSS and OS (Table 1). CONCLUSIONS: RT to recurrence sites might have no effects on oncological outcomes in patients who experienced local recurrence and/or pelvic lymph node metastases after RC. Download PPTDownload PPT Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e342 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Naoki Fujita More articles by this author Toshikazu Tanaka More articles by this author Shogo Hosogoe More articles by this author Noritaka Ishii More articles by this author Masaki Momota More articles by this author Hiroyuki Ito More articles by this author Ikuya Iwabuchi More articles by this author Takahiro Yoneyama More articles by this author Yasuhiro Hashimoto More articles by this author Chikara Ohyama More articles by this author Masahiko Aoki More articles by this author Shingo Hatakeyama More articles by this author Expand All Advertisement PDF downloadLoading ...