Mp76-10 Prior Radiation Therapy Is Associated With Increased Risk of Intra-Operative Complications in Patients Undergoing Primary Inflatable Penile Prosthesis Placement: Results From a Large Multi-Institutional Collaborative

You have accessJournal of UrologySexual Function/Dysfunction: Surgical Therapy II (MP76)1 May 2024MP76-10 PRIOR RADIATION THERAPY IS ASSOCIATED WITH INCREASED RISK OF INTRA-OPERATIVE COMPLICATIONS IN PATIENTS UNDERGOING PRIMARY INFLATABLE PENILE PROSTHESIS PLACEMENT: RESULTS FROM A LARGE MULTI-INSTITUTIONAL COLLABORATIVE Zafardjan Dalimov, Chrystal Chang, David W. Barham, Muhammed Hammad, Jake Miller, Robert Andrianne, Arthur L. L. Burnett, Kelli Gross, Georgios Hatzichristodoulou, James Hotaling, Tung-Chin Hsieh, Lawrence C. Jenkins, James M. Jones, Aaron Lentz, Vaibhav Modgil, Daniar Osmonov, Sung Hun Park, Ian Pearce, Paul Perito, Hossein Sadeghi-Nejad, Maxime Sempels, Alfredo Suarez-Sarmiento, Koenraad van Renterghem, J. Nicholas Warner, Matthew Ziegelmann, Faysal A. Yafi, Martin S. Gross, and Jay Simhan Zafardjan DalimovZafardjan Dalimov , Chrystal ChangChrystal Chang , David W. BarhamDavid W. Barham , Muhammed HammadMuhammed Hammad , Jake MillerJake Miller , Robert AndrianneRobert Andrianne , Arthur L. L. BurnettArthur L. L. Burnett , Kelli GrossKelli Gross , Georgios HatzichristodoulouGeorgios Hatzichristodoulou , James HotalingJames Hotaling , Tung-Chin HsiehTung-Chin Hsieh , Lawrence C. JenkinsLawrence C. Jenkins , James M. JonesJames M. Jones , Aaron LentzAaron Lentz , Vaibhav ModgilVaibhav Modgil , Daniar OsmonovDaniar Osmonov , Sung Hun ParkSung Hun Park , Ian PearceIan Pearce , Paul PeritoPaul Perito , Hossein Sadeghi-NejadHossein Sadeghi-Nejad , Maxime SempelsMaxime Sempels , Alfredo Suarez-SarmientoAlfredo Suarez-Sarmiento , Koenraad van RenterghemKoenraad van Renterghem , J. Nicholas WarnerJ. Nicholas Warner , Matthew ZiegelmannMatthew Ziegelmann , Faysal A. YafiFaysal A. Yafi , Martin S. GrossMartin S. Gross , and Jay SimhanJay Simhan View All Author Informationhttps://doi.org/10.1097/01.JU.0001009484.98400.42.10AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Radiation therapy (RT) can predispose the onset of corporal fibrosis and microvascular injury thus contributing to refractory erectile dysfunction. In this study, we assess intra-operative and post-operative outcomes following primary Inflatable Penile Prosthesis (IPP) implantation among patients with or without prior history of RT. METHODS: We performed a multicenter, retrospective analysis of men undergoing primary IPP placement between January 2015 and July 2021. A total of 3530 patients were identified, of which 3319 had no prior history of RT and 211 patients had history of RT. After 1:1 propensity score matching for all confounding variables, patients with a history of RT were compared to nonradiated patients for intra-operative and post-operative outcomes. Chi-square and Mann-Whitney tests were used for statistical analysis for categorial and continuous variables respectively. For multivariable analysis, we used a forward stepwise model and included significant variables found on pre-operative characteristics of patients. Kaplan-Meier time to event analysis were compared with Mantel-Cox log-rank test. RESULTS: Patients with history of RT encountered more intra-operative complications (4.3% vs 0.9%, p=0.032); specifically, these men experienced more distal crossover events (1.9% vs 0, p=0.044). On multivariable analysis, history of prior RT (OR 5.29, 95% CI 1.07-26.3, p=0.041) and diabetes mellitus (OR 10.5, 95% CI 2.58-43.5, p=0.01) were associated with increased risk of intra-operative complications. History of obesity (OR 0.11, 95% CI 0.01-0.91, p=0.040) reduced risk of intra-operative complications. There was no difference in early or late post-operative non-infectious complications between both groups and there was also no significant difference in risk of post-operative complications within 24 months on Kaplan-Meier analysis (log rank p=0.9). CONCLUSIONS: In this large multi-institutional cohort, history of RT is an independent predictor of intra-operative complications but not post-operative complications during primary IPP placement. These findings may help inform patient-specific counseling while guiding surgical planning to prevent untoward morbidity during surgery. Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e1246 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Zafardjan Dalimov More articles by this author Chrystal Chang More articles by this author David W. Barham More articles by this author Muhammed Hammad More articles by this author Jake Miller More articles by this author Robert Andrianne More articles by this author Arthur L. L. Burnett More articles by this author Kelli Gross More articles by this author Georgios Hatzichristodoulou More articles by this author James Hotaling More articles by this author Tung-Chin Hsieh More articles by this author Lawrence C. Jenkins More articles by this author James M. Jones More articles by this author Aaron Lentz More articles by this author Vaibhav Modgil More articles by this author Daniar Osmonov More articles by this author Sung Hun Park More articles by this author Ian Pearce More articles by this author Paul Perito More articles by this author Hossein Sadeghi-Nejad More articles by this author Maxime Sempels More articles by this author Alfredo Suarez-Sarmiento More articles by this author Koenraad van Renterghem More articles by this author J. Nicholas Warner More articles by this author Matthew Ziegelmann More articles by this author Faysal A. Yafi More articles by this author Martin S. Gross More articles by this author Jay Simhan More articles by this author Expand All Advertisement PDF downloadLoading ...