Mp09-07 Over 48,000 Baseline Prostate Specific Antigen Measurements in Young Men: A 16-Year Time-Analysis

You have accessJournal of UrologyBenign Prostatic Hyperplasia: Epidemiology, Evaluation & Medical Non-surgical Therapy (MP09)1 May 2024MP09-07 OVER 48,000 BASELINE PROSTATE SPECIFIC ANTIGEN MEASUREMENTS IN YOUNG MEN: A 16-YEAR TIME-ANALYSIS Diego M. Capibaribe, Natalia D. Avilez, Natássia C. C. Truzzi, José C. C. I. Truzzi, Mehrsa Jalalizadeh, and Leonardo O. Reis Diego M. CapibaribeDiego M. Capibaribe , Natalia D. AvilezNatalia D. Avilez , Natássia C. C. TruzziNatássia C. C. Truzzi , José C. C. I. TruzziJosé C. C. I. Truzzi , Mehrsa JalalizadehMehrsa Jalalizadeh , and Leonardo O. ReisLeonardo O. Reis View All Author Informationhttps://doi.org/10.1097/01.JU.0001008920.55771.18.07AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: To broaden the understanding of baseline PSA variations over the last decades in young men. METHODS: We analyzed the baseline total PSA of 48,896 men below the age of 40, grouped into three age groups <30 (n=6123), 30-35 (n=16,118), and 35-40 (n=25,351) years old. Multiple linear regression model predicted the average LogPSA per month as a function of time, age, and testing rate during 16-year period of the data (2003-2018). RESULTS: Average age and standard deviation were 34.5±4.6 years and median PSA±interquartile range was 0.63±0.46 ng/dl with a leftward skew towards zero (81% of results below 1 ng/dl) in all years. The average LogPSA was steadily rising over time, independent of age and testing rate in all three age groups: multiple R-squared = 0.40, estimate=1.211e-05, p<0.0001. Mean/median PSA and age were 0.67/0.57 ng/dL and 36.32/37.23 years in 2003 and 0.91/0.66 ng/dL and 34.87/35.88 years in 2018, p<0.01. CONCLUSIONS: Average baseline PSA is rising in young men. Change in medical routine practice (e.g., reserving the test for those with higher suspicion) and true rise in benign or pathological prostate conditions are possible reasons. Download PPT Source of Funding: Internal grants © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e129 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Diego M. Capibaribe More articles by this author Natalia D. Avilez More articles by this author Natássia C. C. Truzzi More articles by this author José C. C. I. Truzzi More articles by this author Mehrsa Jalalizadeh More articles by this author Leonardo O. Reis More articles by this author Expand All Advertisement PDF downloadLoading ...