Mp13-13 Reproductive Outcomes in Infertile Couples Undergoing Intracytoplasmic Sperm Injection With a Male Partner Exhibiting Chromosomal Translocation or Inversion

You have accessJournal of UrologyInfertility: Epidemiology & Evaluation I (MP13)1 May 2024MP13-13 REPRODUCTIVE OUTCOMES IN INFERTILE COUPLES UNDERGOING INTRACYTOPLASMIC SPERM INJECTION WITH A MALE PARTNER EXHIBITING CHROMOSOMAL TRANSLOCATION OR INVERSION Ying-Long Wu, I-Shen Huang, Eric Yi-Hsiu Huang, Wei-Jen Chen, Cheng-Han Tsai, and William J.S. Huang Ying-Long WuYing-Long Wu , I-Shen HuangI-Shen Huang , Eric Yi-Hsiu HuangEric Yi-Hsiu Huang , Wei-Jen ChenWei-Jen Chen , Cheng-Han TsaiCheng-Han Tsai , and William J.S. HuangWilliam J.S. Huang View All Author Informationhttps://doi.org/10.1097/01.JU.0001008832.14212.d6.13AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Chromosomal abnormalities are a significant etiological factor in male infertility, especially in cases of unexplained or idiopathic origin. In certain instances, chromosomal anomalies, such as translocations or inversions, can lead to testicular dysgenesis and spermatogenic arrest, significantly compromising male fertility. In such scenarios, intracytoplasmic sperm injection (ICSI) using either testicular or ejaculated sperm often represents the primary viable option for achieving biological parenthood. Notably, fertility outcomes in individuals with these chromosomal abnormalities have received limited attention in prior research. This study aims at investigating the prevalence, testicular sperm retrieval rate and the potential impact of chromosomal abnormalities on reproductive outcomes. METHODS: After reviewing the chromosomal analysis of 2240 subfertile men from January 2009 to December 2022, we identified 43 men with either chromosome inversions or translocations. We recorded the presence of azoospermia or oligozoospermia in these individuals and reported the sperm retrieval rate using microdissection testicular sperm extraction. A cohort of 48 men with idiopathic non-obstructive azoospermia (iNOA), matched for age and endocrine, was selected for comparison in terms of sperm retrieval rate and reproductive outcomes. RESULTS: The incidence of chromosome inversions and translocations was 1.1% and 0.8%, respectively. Azoospermia was observed in 91.7% of men with inversions (22/24) and in 84.2% of men with translocations (16/19). Among these azoospermic men with chromosomal abnormalities, the sperm retrieval rate using microdissection testicular sperm extraction was 36.4% in men with inversions (8/22) and 31.3% in men with translocations (5/16), which was comparable to men with iNOA. Although the fertilization rate and clinical pregnancy rate were similar when comparing men with inversions or translocations to men with iNOA, it's important to note that none of the five men with translocations achieved successful deliveries. In contrast, the cumulative live birth rate was 25% for men with inversions (2/8) and 28.6% for men with iNOA (4/14). CONCLUSIONS: Based on these results, men with chromosomal inversions or translocations presenting with azoospermia should not be discouraged from undergoing further testicular sperm retrieval. However, individuals with chromosomal translocations should be properly informed about their suboptimal chances of successful delivery. Source of Funding: This is a study without any conflicts of interest and was not sponsored by any company © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e215 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Ying-Long Wu More articles by this author I-Shen Huang More articles by this author Eric Yi-Hsiu Huang More articles by this author Wei-Jen Chen More articles by this author Cheng-Han Tsai More articles by this author William J.S. Huang More articles by this author Expand All Advertisement PDF downloadLoading ...