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Immunoglobulin A nephropathy (IgAN) is the most common form of primary glomerulonephritis and a major cause of chronic kidney disease and kidney failure worldwide. Recent data on long-term outcomes from a large cohort of patients with IgAN have highlighted that patients with proteinuria <0.88 g/g have high rates of kidney failure within 10 years. This means IgAN cannot be considered benign even when proteinuria is <1 g/day. Early intervention with disease-modifying therapies may be particularly effective early in the natural history of IgAN, before the onset of irreversible kidney fibrosis.
Barratt et al. (Mon,) studied this question.