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Introduction: Gallstone disease is one of the biggest global public health problems. The most common complications associated with gallstone disease include cholecystitis, pancreatitis, and cholangitis. The current study aimed to show that serum lipids have a significant role in the etiology of cholelithiasis. Methods: Before surgery, all patients had blood samples taken. Lipid profile tests including very low-density lipoprotein cholesterol (VLDL-C), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), and total cholesterol (TC) were performed on the serum, which was collected using standard procedures. Results: The results showed that mean serum lipid levels were significantly different (P<0.001) between the patients and the control group. In addition, the study revealed statistically significant differences between the genders (P<0.001); in other words, significant differences were found between males and females in patients and controls in mean serum TC, HDL, and TG levels. On the other hand, the findings of the study indicated a notable rise (P<0.001) in serum TC, triglyceride, and HDL levels in the age category 40-59 years, followed by the age category≥60 years and the age category 29-39 years. Conclusion: Overall, changes in serum lipid profile are a possible consequence of the presence of gallstones; in other words, serum TC, HDL, and TG levels were significantly higher in patients with gallstone disease compared to the control group.
Kadim et al. (Fri,) studied this question.