Effect of Anti-Inflammatory Treatment on Depressive Symptom Severity and Anhedonia in Depressed Individuals With Elevated Inflammation: Systematic Review and Meta-Analysis of Randomized Controlled Trials

Key Points

• The research aims to evaluate the effect of anti-inflammatory treatments on depression severity and anhedonia in individuals with elevated inflammation.
• Conducted a systematic review of randomized controlled trials
• Analyzed the effects of anti-inflammatory treatments on depressive symptoms
• Assessed the relationship between inflammation and treatment outcomes
• Anti-inflammatory treatments showed a reduction in depressive symptom severity and anhedonia
• Findings indicate the potential for improved outcomes with treatment in depressed individuals with heightened inflammation
• Prior mixed findings may be explained by not accounting for inflammatory status