Angiotensin II type 1 receptor blockers (ARBs) may serve as novel treatments for inner ear pathologies associated with hearing loss, tinnitus, and vertigo.
Do angiotensin II type 1 receptor blockers (ARBs) have otoprotective mechanisms that could treat audiovestibular disorders?
This review highlights the potential of repurposing ARBs, which have established safety profiles, as novel treatments for audiovestibular disorders.
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Audiovestibular disorders arising from the inner ear (e.g., hearing loss, tinnitus, vertigo) are widely prevalent in the United States. Yet, medical treatments targeting the underlying pathology of these disorders remain scarce. The practice of repurposing FDA-approved drugs for new therapeutic indications has become increasingly common, offering a lower risk route to treatment development with fewer barriers to implementation, as safety profiles are already established. The renin–angiotensin system (RAS) is well known for its role in blood pressure and fluid balance, and its overactivation induces acute and chronic inflammation and oxidative stress. This review discusses existing evidence and proposed otoprotective mechanisms of RAS inhibition, specifically using angiotensin II type 1 receptor blockers (ARBs), which support the repurposing of these medications as novel treatments to affect the inner ear pathologies that underlay hearing loss, tinnitus, and vertigo.
Podhajsky et al. (Fri,) reported a other. Angiotensin II type 1 receptor blockers (ARBs) may serve as novel treatments for inner ear pathologies associated with hearing loss, tinnitus, and vertigo.