Carrier-free water-soluble porphyrin nanoparticles as highly effective photosensitizers for photodynamic therapy

Key Points

• The aim is to develop porphyrin nanoparticles as effective photosensitizers for photodynamic therapy.
• Synthesize three porphyrin derivatives with varying hydrophilic and hydrophobic side chains.
• Formulate nanoparticles through nanoprecipitation with different sizes.
• Evaluate the potential of the nanoparticles as photosensitizers.
• Successfully synthesized porphyrin derivatives with distinct side chain ratios.
• Developed nanoparticles of various sizes that are water-soluble.
• Demonstrated the potential of these nanoparticles for effective use in photodynamic therapy.