The highest quartile of Atherogenic Index of Plasma (AIP) was associated with increased odds of cardiovascular disease (OR = 1.73) and significantly higher odds for heart attack (OR = 2.53) in younger
Does an elevated atherogenic index of plasma (AIP) increase the odds of prevalent cardiovascular disease in US adults?
Elevated atherogenic index of plasma is an independent predictor of prevalent cardiovascular disease, particularly in adults under 55, and exhibits a U-shaped relationship with congestive heart failure.
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Background The association between the atherogenic index of plasma (AIP) and different cardiovascular disease (CVD) outcomes remains insufficiently studied. Methods Data from 16,302 US adults in NHANES 2005–2020 were analyzed. CVD outcomes included congestive heart failure, coronary heart disease, angina, heart attack, and stroke. Multivariable logistic regression models assessed the linear association between AIP and CVD. Restricted cubic splines were used to examine potential nonlinear relationships, whereas threshold effect analysis identified inflection points. Stratified analyses explored interactions between AIP and covariates. Results Compared with the lowest quartile, the highest AIP quartile was associated with increased odds of overall CVD (OR = 1.73, 95% CI = 1.20–2.52, p for trend = 0.001), coronary heart disease (OR = 2.20, 95% CI = 1.20–4.25, p for trend = 0.013), and heart attack (OR = 2.53, 95% CI = 1.42–4.74, p for trend = 0.008). A U‐shaped relationship was observed between AIP and congestive heart failure ( p overall = 0.0004, p nonlinear = 0.002), with a sharp odds increase when AIP exceeded 0.22 (OR = 3.40, 95% CI = 1.81–6.38, p < 0.01). Subgroup analysis revealed a significant age interaction: Among adults younger than 55 years, each AIP increment was associated with higher odds of CVD (OR = 2.53, 95% CI = 1.60–3.98, p = 0.001), heart attack (OR = 2.58, 95% CI = 1.21–5.54, p = 0.014), and stroke (OR = 2.98, 95% CI = 1.44–6.17, p = 0.003). Conclusion Elevated AIP is an independent predictor of CVD, coronary heart disease, and heart attack, particularly in younger adults (< 55 years). A U‐shaped relationship was identified between AIP and congestive heart failure. These findings highlight AIP as a valuable biomarker for CVD risk assessment and emphasize the importance of age‐specific intervention strategies targeting different CVD outcomes.
Hu et al. (Thu,) reported a other. The highest quartile of Atherogenic Index of Plasma (AIP) was associated with increased odds of cardiovascular disease (OR = 1.73) and significantly higher odds for heart attack (OR = 2.53) in younger.