Abstract Background Childhood obesity is a pressing health crisis of epidemic proportions. Bariatric surgery (BS) is an effective treatment for weight loss however its role in the paediatric and adolescent population is contentious owing to the paucity of weight specific and generalised health outcomes. This systematic review and meta-analysis aimed to assess the impact of paediatric BS on bone health. Methods This prospectively registered systematic review (PROSPERO ID: CRD42023432035) was performed in accordance with PRISMA guidelines. We searched MEDLINE (1946-1928 September 2023), EMBASE (1947-1928 September 2023) via the Ovid platform, and the Cochrane Review Library to identify scientific publications reporting bone outcome measures in patients under the age of 18 years who underwent BS. Meta-analysis was undertaken on post-operative weight and bone parameters in paediatric patients following BS. Outcomes were reported as weighted or standardized mean difference with 95 percent confidence intervals. Subgroup analysis by intervention, quality scoring and risk of bias with Eggers testing was assessed. Findings Twelve studies with 681 patients across 5 countries (mean age 17 ± 0.57 years) were included. The quality of studies was rated as high and there was substantial between-study heterogeneity for most factors included in the meta-analysis (I2 from 0% to 99.1%). Patients underwent Roux-en-Y gastric bypass (RYGB, n = 216), sleeve gastrectomy (SG, n = 257), gastric band (n = 184) or intragastric balloon placement (IAGB, n = 24). BS was associated with significant weight reduction, body mass index (BMI) -12.7 kg/m2 (95% c.i. −14.5 to −10.9, P 0.001), with RYGB being most effective, BMI -16.58 kg/m2 (95% c.i. −19.6 to −13.6, P 0.001) at 2 years follow-up. Patients who underwent SG or RYGB had significantly lower lumbar bone mineral density, −0.96 g/cm2 (95% c.i. −0.1 to −0.03, P 0.001), Z scores -1.132 (95% c.i. −1.8 to −0.45, P 0.001) and subtotal body bone mineral density, −0.7 g/cm2 (95% c.i. −1.2 to −0.2, P 0.001) following surgery. This was not observed in patients who had IAGB or gastric bands. There were significantly higher surrogates of bone resorption, C-terminal telopeptide of type 1 collagen 0.22 ng/ml (95% c.i. 0.12–0.32, P 0.001) and osteocalcin, 10.83 ng/ml (95% c.i. 6.01–15.67, P 0.001) at 2 years and a significant reduction in calcium levels following BS, −3.78 mg/dl (95% c.i. −6.1 to −1.5, P 0.001). There was no difference in 25-hydroxyvitamin D, phosphate, bone alkaline phosphatase, procollagen type 1 N propeptide or parathyroid hormone. Interpretation BS effectively reduces weight in paediatric patients, but RYGB and SG may have adverse effects on bone health in the medium term. It is crucial to monitor and support bone health through appropriate nutritional supplementation and judicious follow-up. Long-term data is needed to fully understand the clinical implications of these findings on bone outcomes.
Mitra et al. (Thu,) studied this question.