The direct functionalization of inert C(sp3)-H bonds is extremely attractive for constructing high-added-value molecules in synthetic chemistry. Herein, a metal-free and operationally simple method for the convenient synthesis of diaziridines is developed and affords moderate to good yields under mild reaction conditions. Various C-H precursors, including simple alkanes, free alcohols, esters, ethers, halides, nitriles, and heterocycles, were successfully utilized. Moreover, the synthesis of medicinally relevant heterocycles further highlights the synthetic potential of this strategy.
Wang et al. (Thu,) studied this question.