What question did this study set out to answer?

To evaluate the prognostic implications of vaginal invasion, parametrial invasion, and lymph node metastasis in patients with locally advanced cervical cancer undergoing concurrent chemoradiotherapy.

February 2, 2026Open Access

Reappraisal of the prognostic significance of vaginal invasion, parametrial invasion and lymph node metastasis in locally advanced cervical cancer patients receiving concurrent chemoradiotherapy: a multi-center large cohort study

Key Points

To evaluate the prognostic implications of vaginal invasion, parametrial invasion, and lymph node metastasis in patients with locally advanced cervical cancer undergoing concurrent chemoradiotherapy.
Analyzed a large cohort of patients with locally advanced cervical cancer
Assessed the impact of vaginal invasion, parametrial invasion, and lymph node metastasis on survival
Constructed and validated a nomogram for prognosis differentiation
Lymph node metastasis significantly worsens survival outcomes for patients with vaginal invasion
Parametrial invasion does not affect prognosis as much as lymph node metastasis
The nomogram provides better prognostic accuracy compared to the FIGO staging system

Abstract

LNM would impair the survival for patients with VI not those with PI and a nomogram was constructed and validated to better differentiate the prognosis for LACC patients than FIGO staging system.

Reappraisal of the prognostic significance of vaginal invasion, parametrial invasion and lymph node metastasis in locally advanced cervical cancer patients receiving concurrent chemoradiotherapy: a multi-center large cohort study

Key Points

Abstract

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