What question did this study set out to answer?

This research aims to explore the relationship between gut microbiome changes and sarcopenia through fecal microbiota transplantation in mice.

February 2, 2026Open Access

Microbiome from mice receiving FMT from sarcopenia patients

Key Points

This research aims to explore the relationship between gut microbiome changes and sarcopenia through fecal microbiota transplantation in mice.
Conducted fecal microbiota transplantation (FMT) in male germ-free (GF) mice.
Divided mice into three groups: healthy individuals, sarcopenia patients, and sarcopenia patients with probiotics.
Analyzed gut microbiomes, metabolites, inflammatory factors, muscle mass, and muscle functions.
FMT from sarcopenia patients altered gut microbiome composition in mice.
Probiotic supplementation showed potential effects on muscle mass and function.
Increased inflammatory factors were noted in mice receiving transplants from sarcopenia patients.

Abstract

With the acceleration of the global aging process, healthy aging is a topic of substantial current interest. Sarcopenia is a progressive and generalized skeletal muscle disorder involving the accelerated loss of muscle mass and function, which is associated with the gut microbiome. To investigate the intervention between aging-related gut microbiome and sarcopenia, we conducted fecal microbiota transplantation (FMT) experiments on male germ-free (GF) mice, dividing them into three groups: those receiving transplants from healthy elderly individuals (HM group), those receiving from sarcopenia patients (SM group), and a subgroup of the SM group supplemented with probiotic BFS1243 (SML group). And then, those gut microbiomes and their metabolites, inflammatory factors, muscle mass, muscle functions, etc. were be detected.

Microbiome from mice receiving FMT from sarcopenia patients

Key Points

Abstract

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