Asymmetric photoenzymatic synthesis of chiral γ-acyloxybutenolides from 2-furoic acid in 2-methyltetrahydrofuran: from batch to flow process

Key Points

• This research investigates a new method for producing chiral γ-acyloxybutenolides from 2-furoic acid.
• Developed a one-pot photoenzymatic synthesis method.
• Utilized 2-methyltetrahydrofuran as the solvent.
• Explored the transition from batch to flow processing.
• Successfully synthesized chiral γ-acyloxybutenolides.
• Demonstrated the effectiveness of the biobased process.