What question did this study set out to answer?

The aim is to explore a cost-effective strategy for improving healthcare through decentralized FDA systems and pragmatic trials.

February 6, 2026Open Access

How to Prevent a Year of Death and Suffering for 84 Cents

Key Points

The aim is to explore a cost-effective strategy for improving healthcare through decentralized FDA systems and pragmatic trials.
Allocated $21.8 billion annually to funding a decentralized FDA
Automated efficacy testing using pragmatic clinical trials
Integrated treatment testing into standard healthcare practices
Cleared a backlog of 443 years of treatment testing within 36 years
Achieved a return on investment of 637:1
Projected savings of 10.7 billion deaths and $58.6 billion in annual research and development costs

Abstract

By allocating 21. 8B/year to a decentralized FDA, automating efficacy testing through pragmatic clinical trials integrated into standard healthcare, this clears the 443 years (95% CI: 324 years-712 years) treatment testing backlog in 36 years (95% CI: 11. 6 years-77. 2 years), delivering 637: 1 (95% CI: 569: 1-790: 1) ROI, saving 10. 7B deaths (95% CI: 7. 39B deaths-16. 2B deaths), and generating 58. 6B (95% CI: 49. 2B-73. 1B) in annual R&D savings at 0. 841 (95% CI: 0. 242-1. 75) /DALY (97. 7% (95% CI: 97. 5%-98. 9%) cost reduction, 12. 3x (95% CI: 4. 19x-61. 3x) capacity increase).

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Cite This Study

Mike P. Sinn (Wed,) studied this question.

synapsesocial.com/papers/698586118f7c464f23009fbf https://doi.org/https://doi.org/10.5281/zenodo.18243914

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