Apixaban provided greater absolute benefits for stroke prevention in elderly patients with atrial fibrillation compared to warfarin, consistent across all age groups.
Does apixaban improve stroke prevention compared to warfarin in patients with atrial fibrillation across different age groups?
Apixaban provides consistent relative benefits over warfarin for stroke prevention in AF across all age groups, with greater absolute benefits in older patients.
The benefits of apixaban vs. warfarin were consistent in patients with AF regardless of age. Owing to the higher risk at older age, the absolute benefits of apixaban were greater in the elderly.
Halvorsen et al. (2014) studied this question. Apixaban provided greater absolute benefits for stroke prevention in elderly patients with atrial fibrillation compared to warfarin, consistent across all age groups.