What question did this study set out to answer?

This research aims to understand how aneuploidy contributes to tumor evolution in colorectal cancer.

February 8, 2026

Holding the Line: Negative Selection Maintains the Karyotype in Metastatic Colorectal Cancer

HOHajime OkadaTel Aviv University RSRachel SlutskyTel Aviv University UBUri Ben-DavidTel Aviv University

Key Points

This research aims to understand how aneuploidy contributes to tumor evolution in colorectal cancer.
Longitudinal analysis of 755 samples from 167 colorectal cancer patients
Examination of temporal dynamics of karyotype evolution
Identified specific patterns of karyotype changes over time
Highlighted the role of negative selection in maintaining karyotype integrity

Abstract

Summary: Aneuploidy is prevalent across human cancers, yet its specific contributions to tumor evolution remain poorly understood. In this issue, Cross, Nowinski, Cresswell, Mossner, and colleagues present a longitudinal analysis of 755 samples from 167 patients with colorectal cancer, uncovering the temporal dynamics of karyotype evolution in this tumor type. See related article by Cross et al., p. 218

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