Avoiding significant patient-prosthesis mismatch after surgical aortic valve replacement was associated with greater regression in left ventricular mass index (median -33 vs -14.5 g/m2) and improved functional capacity in patients with severe aortic stenosis.
Observational (n=91)
Yes
Does significant patient-prosthesis mismatch reduce left ventricular mass index regression and functional capacity improvement in patients undergoing surgical aortic valve replacement for severe aortic stenosis?
Avoiding significant patient-prosthesis mismatch after surgical aortic valve replacement leads to better regression of left ventricular mass index and greater improvement in functional capacity, though it does not significantly change left ventricular geometry.
Effect estimate: OR 1.021 for ΔLVMi change associated with significant PPM (95% CI 95% CI 1.001 to 1.041)
Absolute Event Rate: -33% vs -14.5%
p-value: p=0.037 for ΔLVMi difference; 0.043 for multivariate association
Avoiding significant PPM provides better regression in LVMi and greater improvement in functional capacity; however, it is not sufficient for a significant change in left ventricular geometr y.
Ayyıldız et al. (Fri,) conducted a observational in Patients undergoing isolated surgical aortic valve replacement for severe aortic stenosis (n=91). Avoidance of significant patient-prosthesis mismatch (PPM) defined by indexed effective orifice area (iEOA) thresholds per VARC-3 criteria vs. Significant patient-prosthesis mismatch as per VARC-3 criteria was evaluated on Change in left ventricular mass index (ΔLVMi) postoperatively compared between patients with insignificant versus significant PPM (OR 1.021 for ΔLVMi change associated with significant PPM, 95% CI 95% CI 1.001 to 1.041, p=0.037 for ΔLVMi difference; 0.043 for multivariate association). Avoiding significant patient-prosthesis mismatch after surgical aortic valve replacement was associated with greater regression in left ventricular mass index (median -33 vs -14.5 g/m2) and improved functional capacity in patients with severe aortic stenosis.