What is the clinical evidence from this study?

Study design: Case Report. Population: Hereditary transthyretin (TTR) cardiac amyloidosis with Ser43Asn mutation (n=1). Intervention: Left bundle branch area pacing (LBBAP). Primary outcome: Symptoms and hemodynamic parameters.

What does this research mean for the field?

Left bundle branch area pacing improves symptoms and hemodynamic parameters in a patient with hereditary transthyretin cardiac amyloidosis with Ser43Asn mutation. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To examine the effects of left bundle branch area pacing in a patient with hereditary transthyretin cardiac amyloidosis.

February 11, 2026

Left Bundle Branch Area Pacing for Cardiac Amyloidosis With Ser43Asn Mutant Transthyretin: A Case Report

Key Result

Left bundle branch area pacing improved symptoms and hemodynamic parameters in a patient with Ser43Asn mutant hereditary transthyretin cardiac amyloidosis and 2:1 atrioventricular block.

Key Points

To examine the effects of left bundle branch area pacing in a patient with hereditary transthyretin cardiac amyloidosis.
Case report of a patient with hereditary TTR amyloidosis and 2:1 atrioventricular block.
Implementation of left bundle branch area pacing as an intervention.
Monitoring of symptoms and hemodynamic parameters post-intervention.
Improvement in symptoms following left bundle branch area pacing.
Enhanced hemodynamic parameters were observed.
Documentation of the first case of Ser43Asn TTR amyloidosis treated with LBBAP.

Study Design

Type

Case Report (n=1)

Structured PICO

Does left bundle branch area pacing improve symptoms and hemodynamics in a patient with hereditary TTR amyloidosis and AV block?

Population

1 patient with hereditary TTR amyloidosis (Ser43Asn mutant), 2:1 atrioventricular block (second-degree), wide QRS escape rhythm, and reduced ejection fraction.

Intervention

Left bundle branch area pacing (LBBAP)

Outcome

Improvement in symptoms and hemodynamic parameters

This is the first documented case demonstrating that left bundle branch area pacing can improve symptoms and hemodynamics in a patient with Ser43Asn mutant transthyretin cardiac amyloidosis and AV block.

Abstract

ABSTRACT Hereditary transthyretin (TTR) cardiac amyloidosis is a rare infiltrative cardiomyopathy. Involvement of the cardiac conduction system may lead to atrioventricular block. Left bundle branch area pacing (LBBAP) represents an emerging pacing strategy. We report a case of hereditary TTR amyloidosis with 2:1 atrioventricular block (second‐degree), a wide QRS escape rhythm, and reduced ejection fraction, in which LBBAP improved symptoms and hemodynamic parameters. To our knowledge, this is the first documented case of Ser43Asn TTR amyloidosis managed with LBBAP.

AIに質問

Bookmark

Cite This Study

Yao et al. (Sun,) conducted a case report in Hereditary transthyretin (TTR) cardiac amyloidosis with Ser43Asn mutation (n=1). Left bundle branch area pacing (LBBAP) was evaluated on Symptoms and hemodynamic parameters. Left bundle branch area pacing improved symptoms and hemodynamic parameters in a patient with Ser43Asn mutant hereditary transthyretin cardiac amyloidosis and 2:1 atrioventricular block.

synapsesocial.com/papers/698c1c33267fb587c655e720 https://doi.org/https://doi.org/10.1002/ccd.70505

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

AIに質問

Bookmark