What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Adults aged 35-65 years in northeastern Iran from the MASHAD cohort, assessed for hypertension (n=9438). Intervention: Surrogate insulin resistance indices (TyG, Tg/HDL-c, METS-IR, CHG) vs. No insulin resistance surrogate indices (baseline risk). Primary outcome: Association of surrogate insulin resistance indices with prevalence of hypertension (defined as BP ≥140/90 mmHg or use of antihypertensive medication) (OR 1.234 per 1 SD increase in TyG; OR 1.081 per 1 SD increase in Tg/HDL-c; OR 1.525 per 1 SD increase in METS-IR; OR 1.099 per 1 SD increase in CHG, p=<0.001 for all indices).

What does this research mean for the field?

Each 1-unit increase in the METS-IR index is associated with a 52.5% increase in the odds of hypertension after full adjustment for confounding factors. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To investigate the relationship between insulin resistance surrogate indices and hypertension in a population cohort.

February 12, 2026Open Access

Association of four insulin resistance surrogate indices and hypertension in the MASHAD cohort study population: a cross-sectional study

Q: What are the key findings of this study?

Surrogate insulin resistance indices were independently associated with hypertension, with each 1 SD increase in METS-IR linked to 52.5% higher odds of hypertension, and TyG index linked to 23.4% higher odds, in Iranian adults aged 35-65.

Q: What does this research mean for the field?

Each 1-unit increase in the METS-IR index is associated with a 52.5% increase in the odds of hypertension after full adjustment for confounding factors. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Q: What question did this study set out to answer?

To investigate the relationship between insulin resistance surrogate indices and hypertension in a population cohort.

ATAli TajikMashhad University of Medical Sciences MGM Ghayour-MobarhanMashhad University of Medical Sciences SDS DarroudiUniversity of Modena and Reggio Emilia

Key Result

Surrogate insulin resistance indices were independently associated with hypertension, with each 1 SD increase in METS-IR linked to 52.5% higher odds of hypertension, and TyG index linked to 23.4% higher odds, in Iranian adults aged 35-65.

Key Points

To investigate the relationship between insulin resistance surrogate indices and hypertension in a population cohort.
Cross-sectional design
Assessment of four surrogate insulin resistance indices
Evaluation of hypertension prevalence in cohort members
Statistical analysis of associations between indices and blood pressure levels
Surrogate insulin resistance indices were independently associated with elevated blood pressure.
Findings suggest that these indices may aid in identifying cardiometabolic risks.

Study Design

Type

Cross-Sectional (n=9,438)

Multicenter

Structured PICO

Are elevated surrogate insulin resistance indices (TyG, Tg/HDL-c, METS-IR, CHG) associated with higher odds of hypertension in adults?

Population

9,438 adults (aged 35-65 years) from the MASHAD cohort, including 2,943 with hypertension and 6,495 without hypertension, 39.8% male, based in Mashhad, Iran.

Intervention

Assessment of four surrogate insulin resistance (IR) indices: Triglyceride-Glucose index (TyG), Triglyceride to HDL cholesterol ratio (Tg/HDL-c), Metabolic Score for Insulin Resistance (METS-IR), and Cholesterol-HDL-Glucose (CHG) index.

Outcome

Presence of hypertension (defined as blood pressure >140/90 mmHg or use of anti-hypertensive medications).

Surrogate insulin resistance indices, particularly METS-IR and TyG, are independently associated with hypertension and may help identify individuals with early cardiometabolic risk.

Main Result

Effect estimate: OR 1.234 per 1 SD increase in TyG; OR 1.081 per 1 SD increase in Tg/HDL-c; OR 1.525 per 1 SD increase in METS-IR; OR 1.099 per 1 SD increase in CHG

p-value: p=<0.001 for all indices

Limitations

Cross-sectional design precludes determination of causality due to temporal ambiguity
Potential recall bias due to self-reported data
Findings reflect association but cannot predict incident hypertension
Study population limited to northeastern Iran, may limit generalizability

Abstract

Surrogate IR indices were independently associated with hypertension, reflecting underlying metabolic dysfunction linked to blood pressure elevation. These markers may complement traditional assessments by helping to identify individuals with early or latent cardiometabolic risk.

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Cite This Study

Tajik et al. (Mon,) conducted a cross-sectional in Adults aged 35-65 years in northeastern Iran from the MASHAD cohort, assessed for hypertension (n=9,438). Surrogate insulin resistance indices (TyG, Tg/HDL-c, METS-IR, CHG) vs. No insulin resistance surrogate indices (baseline risk) was evaluated on Association of surrogate insulin resistance indices with prevalence of hypertension (defined as BP ≥140/90 mmHg or use of antihypertensive medication) (OR 1.234 per 1 SD increase in TyG; OR 1.081 per 1 SD increase in Tg/HDL-c; OR 1.525 per 1 SD increase in METS-IR; OR 1.099 per 1 SD increase in CHG, p=<0.001 for all indices). Surrogate insulin resistance indices were independently associated with hypertension, with each 1 SD increase in METS-IR linked to 52.5% higher odds of hypertension, and TyG index linked to 23.4% higher odds, in Iranian adults aged 35-65.

synapsesocial.com/papers/698d6d445be6419ac0d5236f https://doi.org/https://doi.org/10.1186/s40001-026-03843-w

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