Dual inhibition of ERα/NF-κB pathways coupled with sonodynamic therapy via a multifunctional AIEgen | Synapse
February 14, 2026
Dual inhibition of ERα/NF-κB pathways coupled with sonodynamic therapy via a multifunctional AIEgen
Key Points
The research aims to explore the effects of a trifunctional sonosensitizer on ERα and NF-κB pathways for cancer therapy.
Developed TBEP, a multifunctional sonosensitizer with AIE properties.
Utilized ultrasound to trigger reactive oxygen species (ROS) generation.
Targeted ERα using estradiol and anti-inflammatory effects via pterostilbene.
TBEP effectively generated ROS upon ultrasound exposure.
Demonstrated significant inhibition of ERα and NF-κB pathways.
Showed potential for reducing inflammation in cancer treatment.
Abstract
Here we report TBEP, a trifunctional sonosensitizer integrating AIE characteristics for ultrasound-triggered ROS generation, estradiol-mediated ERα targeting, and pterostilbene-derived anti-inflamation.