Fucoidan/bis-MPA-based dendrimer nanoparticles with intrinsic anti-angiogenic activity for oncology applications

Key Points

• The aim is to explore the anti-angiogenic properties of fucoidan/bis-MPA-based dendrimer nanoparticles for cancer treatment.
• Designed and synthesized dendrimer nanoparticles using fucoidan and bis-MPA.
• Assessed intrinsic anti-angiogenic activity in vitro and in vivo.
• Evaluated suppression of metastasis and therapeutic delivery capabilities.
• The nanoparticles exhibited significant anti-angiogenic activity in experimental models.
• Results showed reduced metastasis in cancer models with nanoparticles administration.
• Therapeutic delivery was enhanced through the nanoparticles.