The impact of predator stress on electroshock seizure threshold: insights into GABAergic, glutamatergic, and serotonergic pathways in mice

Key Points

• The research investigates how predator stress affects seizure susceptibility and underlying neurotransmitter pathways.
• Examined seizure threshold in mice under predator stress.
• Analyzed hippocampal expression of GABAAα1R and 5-HT1AR.
• Monitored NF-κB activation and ERK signaling levels.
• Applied pharmacological modulation to neurotransmitter pathways.
• Predator stress increased susceptibility to seizures.
• Downregulation of hippocampal GABAAα1R and 5-HT1AR was observed.
• Enhanced NF-κB activation and reduced ERK signaling were identified.
• Pharmacological interventions reversed the stress-induced decrease in seizure threshold.