Copper-catalyzed 1,2-Carboesterification of 1,3-Enynes via Polarity-Matched Hydrogen Atom Transfer | Synapse
February 19, 2026
Copper-catalyzed 1,2-Carboesterification of 1,3-Enynes via Polarity-Matched Hydrogen Atom Transfer
Key Points
This research aims to develop a copper-catalyzed method for the selective modification of C-H bonds using a hydrogen atom transfer strategy.
Employed copper as a catalyst in the reaction process.
Utilized 1,3-enynes as substrates for carboesterification.
Focused on polarity-matched hydrogen atom transfer to achieve selectivity.
Successful transformation of 1,3-enynes into carboesters.
Achieved high selectivity in the C-H activation process.
Demonstrated a novel approach to overcome challenges in synthetic chemistry.
Abstract
The selective and direct transformation and modification of C-H have always been a difficult and hot topic in synthetic chemistry. In recent years, the HAT strategy has been one of...