What does this research mean for the field?

Asymmetric Negishi and Kumada couplings are powerful and versatile tools for constructing chiral molecules with high enantioselectivity. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

The aim is to provide a thorough overview of improvements in asymmetric Negishi and Kumada couplings over recent decades.

February 19, 2026

Asymmetric Negishi and Kumada Couplings

Key Points

The aim is to provide a thorough overview of improvements in asymmetric Negishi and Kumada couplings over recent decades.
Reviewed literature from the 1980s to 2025 on asymmetric couplings
Analyzed enantioselective and enantiospecific reactions
Discussed catalyst developments using nickel, palladium, and cobalt
Explored mechanistic ligand design and its impact on reactions
Demonstrated high levels of enantioselectivity in various transformations
Highlighted the expanding scope of applicability in challenging reactions
Showcased advancements in mechanistic understanding that enhance reaction efficiency

Abstract

This review provides a comprehensive overview of asymmetric Negishi and Kumada crosscoupling reactions, covering key developments from the 1980s through 2025. It examines enantioselective and enantiospecific variants catalyzed by nickel, palladium, and cobalt complexes. The review discusses reaction scope, mechanistic ligand design and mechanistic understanding have enabled increasingly challenging transformations with high enantioselectivity Overall, this review demonstrates the power and versatility of asymmetric Negishi and Kumada couplings as valuable tools for constructing chiral molecules.

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