Forcing the phenyl moiety into the axial position by embedding the 2-pheny-1,3dioxane system in a tricyclic benzomorphan scaffold: Design, synthesis and biological evaluation

Key Points

• The research aims to explore how specific structural arrangements affect interactions with sigma-1 and NMDA receptors.
• Designed and synthesized a tricyclic benzomorphan scaffold containing the 2-pheny-1,3-dioxane system.
• Conducted biological evaluations to assess receptor interactions.
• Utilized qualitative analysis to understand the impact of relative configuration and substitution patterns.
• Identified significant interactions of the synthesized compounds with sigma-1 receptors.
• Demonstrated varying effects on the PCP binding site of NMDA receptors depending on the configuration.
• Suggests optimization of scaffold design can enhance pharmacological activity.