Clickable polyamidosaccharides: accessing bottlebrush inspired hyaluronic acid glycopolymers for CD44 targeting of breast cancer cells

Key Points

• The research aims to develop clickable hyaluronic acid glycopolymers for targeting CD44 in breast cancer cells.
• Synthesis of clickable polyamidosaccharides inspired by bottlebrush structures
• Assessment of CD44 binding affinity
• Evaluation of tumor growth inhibition in vitro
• Glycopolymers showed enhanced CD44 receptor binding
• Significant reduction in breast cancer cell proliferation observed
• Improved targeting efficacy compared to conventional approaches