What question did this study set out to answer?

To document the features of a rare case of adamantinoma-like Ewing sarcoma with an NRAS Q61R mutation.

February 22, 2026

Adamantinoma-like Ewing sarcoma with NRAS Q61R mutation: a hitherto unreported mutation in a case from the nasal cavity

Key Points

To document the features of a rare case of adamantinoma-like Ewing sarcoma with an NRAS Q61R mutation.
Case report of a 75-year-old lady with ALES in the nasal septum.
Evaluation of clinico-pathological features and mutation identification.
Identified NRAS Q61R mutation in adamantinoma-like Ewing sarcoma.
Demonstrated distinct characteristics of ALES compared to conventional Ewing sarcoma.

Abstract

Adamantinoma-like Ewing sarcoma (ALES) is a rare malignant neoplasm currently classified as a subtype of Ewing sarcoma (ES) and is similarly molecularly defined by a FET-ETS translocation. However, ALES demonstrates some morphologic and immunohistochemical features distinct from conventional ES. Here, we present the clinico-pathological features of a case of ALES in the nasal septum of a 75-year-old lady, with a hitherto unreported NRAS Q61R mutation. Further studies are required to investigate the prevalence and clinical significance of the NRAS Q61R mutation in ALES.

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Adamantinoma-like Ewing sarcoma with NRAS Q61R mutation: a hitherto unreported mutation in a case from the nasal cavity

Key Points

Abstract

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