What question did this study set out to answer?

To evaluate the effectiveness of omega-3 fatty acids as an adjunct therapy in children and adolescents with major depressive disorder.

February 22, 2026

RCT: Omega‐3 fatty acids not supported as adjunct therapy for pediatric depression

Key Points

To evaluate the effectiveness of omega-3 fatty acids as an adjunct therapy in children and adolescents with major depressive disorder.
Conducted a randomized clinical trial (RCT) with a pediatric population.
Administered omega-3 fatty acids (EPA and DHA) along with antidepressants.
Compared the omega-3 treatment group to a placebo group.
Omega-3 fatty acids did not show significant improvement over placebo in treating major depressive disorder.
No substantial differences in depressive symptoms reported between the two groups.

Abstract

A randomized clinical trial (RCT) of children and adolescents found that omega‐3 fatty acids such as EPA and DHA, as an adjunct to antidepressants, did not outperform placebo in youths with major depressive disorder (MDD).

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