What question did this study set out to answer?

This report aims to discuss a rare case of Stevens-Johnson syndrome linked to amitriptyline use.

February 24, 2026Clinical Case Reports0 citationsOpen Access

Amitriptyline Induced Life‐Threatening Steven–Johnson Syndrome: Case Report

WDWondwosen Mengist Dereje LYLidya YalewUniversity of Gondar NTNardos TafesseUniversity of Gondar

Key Points

This report aims to discuss a rare case of Stevens-Johnson syndrome linked to amitriptyline use.
Reviewed clinical presentation and diagnosis of Stevens-Johnson syndrome.
Investigated the patient's medication history highlighting amitriptyline usage.
Analyzed potential adverse drug reactions associated with amitriptyline.
Identified complete clinical features of Stevens-Johnson syndrome in the patient.
Demonstrated a clear temporal relation between amitriptyline administration and syndrome onset.
Highlighted the life-threatening nature of the reaction and the need for immediate intervention.

Abstract

ABSTRACT Stevens–Johnson syndrome is one of the few dermatological emergencies in clinical practice. The syndrome is often secondary to the usage of drugs, of which allopurinol, penicillins, sulfa drugs, ibuprofen, sodium valproate, phenytoin, lamotrigine, and carbamazepine are commonly implicated. Stevens–Johnson syndrome due to amitriptyline combination has not been reported in the literature before.

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Cite This Study

Dereje et al. (Sun,) studied this question.

synapsesocial.com/papers/699d3fb3de8e28729cf645b2 https://doi.org/https://doi.org/10.1002/ccr3.72129

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