This research aims to explore the effects of TMJ hyperextension on pain modulation pathways in female rats, highlighting sexual dimorphism in responses.
Induced TMJ hyperextension in female rats.
Monitored nociception and pain modulation pathways post-event.
Analyzed differences in pain responses based on gender.
TMJ hyperextension led to increased nociception in female rats.
Dysfunction was observed in pain modulation pathways following hyperextension.
Sexual dimorphism was evident, indicating different pain processing mechanisms.
Abstract
Our findings provide evidence of sexual dimorphism in a novel TMD model caused by a single, transient hyperextension event.